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M94A2612.TXT
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1994-10-25
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Document 2612
DOCN M94A2612
TI HIV/AIDS; concurrent neurosyphilis.
DT 9412
AU Paz RB; Palhares MC; Ueda M; Reference/Training Center-SDT/AIDS Group,
Sao Paulo, Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):264 (abstract no. PB0484). Unique
Identifier : AIDSLINE ICA10/94369963
AB OBJECTIVE: To evaluate the incidence of neurosyphilis in patients (px)
attended at Reference & Training Center for SDT/AIDS, Sao Paulo, Brazil.
METHODS: From 279 HIV positive px with CSN alteration or neurologic
complain clinically assessed by CDC criteria, 376 paired serum/CSF
samples were obtained. According to VDRL/FTA-ABS reactivity the px were
divided into 2 groups: A. 16 px with reactive tests in both samples; B.
101 with reactive tests in serum only. Blood-brain barrier (BBB) status
was evaluated according to REIBER & FELGENHAUER graph method (1987).
HIV-1 antibody (Ab) assays were carried out in paired samples. Lumbar
CSF was analysed for cells count and protein level. RESULTS &
CONCLUSIONS: Intact BBB was observed in 10 px (group A) in one or more
paired samples. Based on clinical data, laboratory findings and from the
analysis of sequential paired samples, of 16 px (group A) none was
suffering from neurosyphilis but 3 had ophtalmic syphilis, indicating
that reactive CSF were due to transudation of specific Ab throug intact
or impaired barrier resulting from other pathologic agents in CNS.
Individuals of group B with impaired BBB but presenting non-reactive CSF
serology for syphilis could be explained by low sensitivity of these
tests in detecting low levels of Ab.
DE Acquired Immunodeficiency Syndrome/*DIAGNOSIS/EPIDEMIOLOGY AIDS-Related
Opportunistic Infections/*DIAGNOSIS/EPIDEMIOLOGY Blood-Brain
Barrier/PHYSIOLOGY Brazil/EPIDEMIOLOGY Cross-Sectional Studies Human
HIV Infections/*DIAGNOSIS/EPIDEMIOLOGY *HIV-1 Incidence
Neurosyphilis/*DIAGNOSIS/EPIDEMIOLOGY Syphilis Serodiagnosis MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).